Sleep Duration Alters Overfeeding-mediated Reduction in Insulin Sensitivity
Authors' conclusion
Overfeeding mediated weight gain reduced liver, adipose, and whole-body insulin sensitivity prominently in individuals with short sleep duration but not in individuals with longer sleep duration. This suggests that promoting adequate sleep during short periods of overeating may prevent detrimental effects on glucose metabolism.
Study context
- Population
- Healthy participants (age 26.9 ± 5.5 years, BMI 25.74 ± 2.45 kg/m²) overfed 40% above weight maintenance calorie requirements for 8 weeks
- Participants
- 28 participants
- Comparison
- Short vs longer habitual sleep duration during 8-week overfeeding
- Primary endpoint
- Insulin sensitivity by 2-step hyperinsulinemic-euglycemic clamp
- Follow-up
- 8 weeks
Methodological detailssleep groups by median sleep duration (5.2 hours/night)
- Sleep groups by median sleep duration (5.2 hours/night)
Primary result
As reported in the abstract
Overfeeding-mediated change in insulin sensitivity, short vs more sleep
- Short sleep vs More sleep: P = 0.01
- Short sleep vs More sleep: P = 0.02
- Short sleep vs More sleep: P = 0.68
- Short sleep vs More sleep: P < 0.01
Further findings
| Outcome | P value |
|---|---|
| Body weight gain, fat gain and fat distribution by sleep duration · 8 weeksNot altered by habitual sleep duration | all P > .15 |
Body weight gain with overfeeding · 8 weeks
- Average body weight gain (all participants)
- 7.3 ± .4 kg
Original publication
Sleep Duration Alters Overfeeding-mediated Reduction in Insulin Sensitivity. J Clin Endocrinol Metab. Published 19 July 2024. doi:10.
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