Overnight wakefulness impairs next-day postprandial glucose in young women independent of sex hormones
Authors' conclusion
One night of wakefulness-as occurs in night shift work-impaired next-morning glucose tolerance in women, independent of ovarian hormone variation. Accordingly, choosing low-glycemic index foods for the first meal after a night shift may help reduce postprandial glucose excursions.
Study context
- Population
- Reproductive-aged women with HbA1c <5.7%completed both conditions
- Participants
- 52 women
- Comparison
- One night of wakefulness vs one night of sleep
Methodological detailslaboratory-based, within-participant crossover
- Laboratory-based
- Within-participant crossover
Primary result
As reported in the abstract
Post-OGTT blood glucose at 60 minutes · next morning
Mean estimated difference
0.58 mmol/L
P = 0.016
Night shift
Difference in peak glucose
0.42 mmol/L
P = 0.037
Night shift
Further findings
| Outcome | Difference | P value |
|---|---|---|
| Pre-OGTT RQLower after night shift | −0.029 | P < 0.001 |
- Pre-OGTT respiratory quotient (RQ) — Adjusting for pre-OGTT RQ attenuated post-OGTT glucose differences between conditions
- P ≥ .097
Fasting glucose, HOMA-IR and leptin-to-adiponectin ratio (LAR)
- Fasting glucose, HOMA-IR and LAR did not differ between conditions
P/E ratio and glucose
- P/E ratio not significantly associated with fasting or postprandial glucose
Original publication
Overnight wakefulness impairs next-day postprandial glucose in young women independent of sex hormones. J Clin Endocrinol Metab. Published 31 January 2026. doi:10.
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