Prognostic value of triglyceride‐derived metabolic parameters for micro‐ and macrovascular complications and mortality in individuals with type 2 diabetes: The Rio de Janeiro type 2 diabetes cohort study
Authors' conclusion
No triglyceride-derived metabolic parameter was predictive of any adverse outcome, either micro- or macrovascular events or mortality, suggesting that they should not be used for risk stratification in individuals with type 2 diabetes.
Study context
- Population
- Individuals with T2D, Rio de Janeiro type 2 diabetes cohort
- Participants
- 667 individuals
- Exposure
- Triglyceride-derived parameters as continuous and tertile variables
- Outcome
- Cardiovascular (total and major cardiovascular events), microvascular (renal, retinopathy, peripheral neuropathy events) outcomes and mortality
- Follow-up
- Median 10.6 years
Methodological detailsmultivariable Cox analyses
- Multivariable Cox analyses
Main finding
As reported in the abstract
Association of TG-derived parameters with adverse outcomes
1st year TyG for retinopathy development/progression, HR per 1-SD increment
1.24
95% CI 1.01–1.53
After further adjustment for LDL-C, HR (95% CI 0.92-1.45), non-significant
1.16
Observational data: associations, not effects.
Further findings
Events during follow-up · median 10.6 years
- Total cardiovascular events
- 212
- Major cardiovascular events
- 172
- All-cause deaths
- 263
- New microalbuminuria
- 124
- Advanced renal function deterioration
- 98
- Retinopathy development/progression
- 154
- Peripheral neuropathy development/progression
- 173
Original publication
Prognostic value of triglyceride‐derived metabolic parameters for micro‐ and macrovascular complications and mortality in individuals with type 2 diabetes: The Rio de Janeiro type 2 diabetes cohort study. Diabet Med. Published 19 February 2026. doi:10.
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