The effect of rapid improvement of blood glucose level on diabetic neuropathy in Korean people with diabetes mellitus
Authors' conclusion
Rapid glycemic improvement was not associated with clinically meaningful short-term worsening of neuropathy. Mild, domain-specific autonomic changes occurred in a minority without painful neuropathy
Study context
- Population
- Korean people with DM undergoing rapid glycemic control
- Participants
- 71 vs 79
- Exposure
- Boramae Neuropathy vs TRIPLE-AXEL
- Boramae Neuropathyn = 71
- TRIPLE-AXELn = 79
- Outcome
- Short-term changes in neuropathy and autonomic function (NTSS-6, MNSI, COMPASS-31)
Methodological detailstwo cohorts
- Two cohorts
Main finding
As reported in the abstract
Boramae: abnormal COMPASS-31 prevalence
36.6% to 29.6%
TRIPLE-AXEL: abnormal COMPASS-31 prevalence
6.3% to 1.3%
Observational data: associations, not effects.
Further findings
HbA1c change
- Boramae: HbA1c decreased
- 11.3 ± 1.4% to 6.9 ± 0.8%
- TRIPLE-AXEL: HbA1c decreased
- 9.5 ± 0.8% to 6.4 ± 0.6%
Safety
New abnormal COMPASS-31 scores (Boramae)
- Developed abnormal COMPASS-31 scores, mainly orthostatic symptoms, without increased neuropathic pain
- 8.5%
Original publication
The effect of rapid improvement of blood glucose level on diabetic neuropathy in Korean people with diabetes mellitus. Diabetes Res Clin Pract. Published 21 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →