Diabetic autonomic neuropathy does not impede improvement in hypoglycaemia awareness in adults: Sub‐study results from the HypoCOMPaSS trial
Authors' conclusion
IAH can be improved in people with T1DM, and a long duration of disease, with and without cardiac autonomic dysfunction. These data suggest that CAN is not a prime driver for modulating IAH reversibility.
Study context
- Population
- Adults with T1D and impaired awareness of hypoglycaemia (Gold score ≥4) in the HypoCOMPaSS trial; mean age 48 years, 62.7% women, mean T1D duration 29 years, mean HbA1c 66 mmol/mol
- Participants
- 83 adults
- Comparison
- Cardiac autonomic neuropathy (CAN) status and change in Gold score
- Primary endpoint
- Change in Gold score by CAN status
Methodological detailssub-study, 24-week, 2 × 2 factorial, All received comparable education and support aimed at avoiding hypoglycaemia and improving awareness
- Sub-study
- 24-week
- 2 × 2 factorial
- All received comparable education and support aimed at avoiding hypoglycaemia and improving awareness
Primary result
As reported in the abstract
Change in Gold score, all participants regardless of autonomic function status
Mean improvement in Gold score
−1.2
95% CI −0.8, −1.6p < 0.001
Further findings
Prevalence of CAN · baseline
- Definite autonomic neuropathy
- 5/83 (6%)
- Possible/early neuropathy
- 11 (13%)
Original publication
Diabetic autonomic neuropathy does not impede improvement in hypoglycaemia awareness in adults: Sub‐study results from the HypoCOMPaSS trial. Diabet Med. Published 13 May 2024. doi:10.
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