The Risk of and Associated Demographic and Laboratory Variables for Amputations for Inpatients with Diabetic Foot Ulcers
Authors' conclusion
Our study identified a high DFU-related amputation risk (44%) among adult patients who were mostly Black and/or Hispanic. The significant risk factors associated with DFU amputation included male sex, low body mass index, smoking, and high levels inflammation or low levels of albumin during admission. Many of these patients required multidisciplinary care and intravenous antibiotic therapy, necessitating a longer length of stay and high readmission rate.
Study context
- Population
- Adults hospitalised with DFU at 3 hospitals of one health system, June 1, 2016–May 31, 2021; 88% non-White race
- Participants
- 650 adults
- Exposure
- Amputation vs no amputation
- Outcome
- Rate of amputation in patients admitted with DFU
- Follow-up
- Index admission
Methodological details3 hospitals, electronic medical records
- 3 hospitals
- Electronic medical records
Main finding
As reported in the abstract
Amputation risk
44%
Observational data: associations, not effects.
Further findings
Demographic factors associated with amputation
- Male sex, OR
- 0.62
- Low BMI, OR
- 0.98
- History of smoking, OR
- 1.45
- Significantly associated with amputation during the study period
Laboratory variables associated with amputation vs no amputation during admission
- Higher erythrocyte sedimentation rate, OR
- 1.01
- Higher C-reactive protein, OR
- 1.05
- Higher white blood cell count, OR
- 1.11
- Low albumin, OR
- 0.41
- Significantly associated
Original publication
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