Corneal confocal microscopy identifies early and definite diabetic cardiac autonomic neuropathy
Authors' conclusion
CCM is a rapid, non-invasive ophthalmic test which could be used to detect early and established CAN.
Study context
- Population
- Individuals with T1D and T2D, and healthy controls238 with diabetes, 37 controls
- Comparison
- Corneal confocal microscopy (CCM) vs cardiac autonomic reflex testing (CARTs) for diagnosing cardiac autonomic neuropathy (CAN)
- Outcome
- Diagnostic utility (ROC AUC, sensitivity/specificity) for identifying early and definite CAN
Performance
As reported in the abstract
Identification of early and definite CAN
- ROC AUC and sensitivity/specificity of CCM comparable to those of CARTs for identifying early and definite CAN
Further findings
CART and corneal nerve measures by CAN severity
- Progressive and significant reduction in DB-HRV, E:I ratio, 30:15 ratio, corneal nerve fibre density (CNFD), corneal nerve branch density (CNBD) and corneal nerve fibre length (CNFL) with increasing severity of CAN
Original publication
Corneal confocal microscopy identifies early and definite diabetic cardiac autonomic neuropathy. Diabetes Res Clin Pract. Published 11 April 2025. doi:10.
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