Association between antidepressants and the risk of diabetic foot ulcers and amputation in antidepressant-naïve type 2 diabetes mellitus patients: A nested case-control study
Authors' conclusion
Caution is advised when administering TCAs and SSRIs in antidepressant-naïve T2DM patients to reduce DFU and the consequent amputation risk.
Study context
- Population
- Antidepressant-naïve patients with T2DM, representative population-based Korean cohort database, 2002–2019nested case-control
- Participants
- 791 vs 3,900
- Comparison
- Antidepressant ever-use vs non-use
- DFUsn = 791
- Controlsn = 3,900reference
- Outcome
- DFU risk
Methodological detailspopulation-based, matched on age, sex, date of T2DM diagnosis and follow-up duration, conditional logistic regression
- Population-based
- Matched on age, sex, date of T2DM diagnosis and follow-up duration
- Conditional logistic regression
Main finding
As reported in the abstract
DFU incidence
- Antidepressant ever-use associated with increased incidence of DFUs vs non-use
- DFU risk increased with increasing cumulative antidepressant dosage, particularly among tricyclic antidepressant (TCA) and SSRI ever-users
Observational data: associations, not effects.
Further findings
- Antidepressant ever-users had higher risk of DFUs requiring amputation, consistent with cumulative dosages of overall antidepressants and TCAs
Original publication
Association between antidepressants and the risk of diabetic foot ulcers and amputation in antidepressant-naïve type 2 diabetes mellitus patients: A nested case-control study. Diabetes Res Clin Pract. Published 24 February 2024. doi:10.
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