Obstructive sleep apnea is associated with cardiac structural and functional alterations in patients with advanced diabetic kidney disease
Authors' conclusion
Moderate-severe OSA is associated with cardiac hypertrophy and chamber dilatation, potentially contributing to cardiovascular risk in advanced DKD.
Study context
- Population
- T2D patients with estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m² and albuminuria (advanced diabetic kidney disease (DKD)); mean age 71.4 ± 9.4 years, 73 % male, eGFR 32.1 ± 12.3 mL/min/1.73 m²
- Participants
- 34 vs 39
- Exposure
- Moderate-severe obstructive sleep apnea (OSA) vs no OSA
- Moderate-severe OSAn = 34
- No OSAn = 39reference
- Outcome
- Cardiac structure and function by transthoracic echocardiography
Main finding
As reported in the abstract
LAVI
P < 0.01
Observational data: associations, not effects.
Further findings
LVMI · higher with moderate-severe OSA
P < 0.01
Right ventricular diameter (RVD) · higher with moderate-severe OSA
P < 0.001
| Outcome | Moderate-severe OSA | No OSA | P value |
|---|---|---|---|
| Global longitudinal strain (GLS)Reduced with moderate-severe OSA | −15.1 ± 3.0 % | −16.6 ± 2.8 % | P < 0.05 |
Left ventricular ejection fraction (LVEF)
- LVEF did not differ
Multivariable linear regression
- Moderate-severe OSA remained significantly associated with LAVI, LVMI, RVD and global longitudinal strain (GLS) but not with LVEF
Original publication
Obstructive sleep apnea is associated with cardiac structural and functional alterations in patients with advanced diabetic kidney disease. Diabetes Res Clin Pract. Published 11 May 2025. doi:10.
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