Impact of the era of diabetes onset in a national care system on the prevalence of retinopathy and microalbuminuria in people living with type 1 diabetes 15 years post‐diagnosis: A cross‐sectional, real‐world observational study
Authors' conclusion
Individuals diagnosed with T1D after 1998 had fewer microvascular complications 15 years post-diagnosis, especially less retinopathy in those with diabetes onset after age 11. This decline highlights the impact of improved care.
Study context
- Population
- Individuals diagnosed with T1D before age 30 in a national healthcare system with structured multidisciplinary endocrinology care
- Participants
- 2,176 individuals
- Exposure
- T1D onset 1985-1998 vs 1998-2009
- Outcome
- Prevalence of diabetic retinopathy and albuminuria
- Follow-up
- 15 years post-diagnosis
Methodological detailsreal-world observational, national care system, Prevalence assessed using generalised estimating equations
- Real-world observational
- National care system
- Prevalence assessed using generalised estimating equations
Main finding
As reported in the abstract
Diabetic retinopathy prevalence, 2001 vs 2022
36.3% vs 21.1%
p < 0.0001
Albuminuria prevalence (adjusted for age and sex), 2001 vs 2022
14.9% vs 7.3%
p < 0.05
Observational data: associations, not effects.
Further findings
HbA1c · poorer in group A
P < 0.0001
Obesity prevalence · higher in group B
P < 0.01
Antihypertensive therapy use · more in group A
P < 0.01
Lipid-lowering therapy use · more in group B
P < 0.0001
LDL-C · poorer in group A
P < 0.001
Original publication
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