Testosterone Treatment and Sexual Function in Men: Secondary Analysis of the T4DM (Testosterone for Diabetes) Trial
An erratum to this article was published (J Clin Endocrinol Metab, 17 Jun 2025 ↗)
Authors' conclusion
Testosterone treatment enhanced sexual desire and, to a lesser extent, erectile function, particularly in older men and those with higher waist circumference or depressive symptoms. Reduced waist circumference and depression independently improved sexual function.
Study context
- Population
- Men aged 50 to 74 years at high risk of, or newly diagnosed with, T2D (via OGTT), 6 Australian centres792 with complete IIEF-15 data
- Participants
- 1,007 men
- Comparison
- Intramuscular testosterone undecanoate vs placebo, alongside a lifestyle program
- Primary endpoint
- Sexual function measured using the IIEF-15 questionnaire
Methodological detailsdouble-blind, placebo-controlled, multicentre
- Double-blind
- Placebo-controlled
- Multicentre
Primary result
As reported in the abstract
IIEF-15 domain scores
- Testosterone improved all 5 IIEF-15 domain scores
- Stronger effects on sexual desire and orgasmic function in older men, and sexual desire in men with higher depression scores
Further findings
Baseline domain scores
- Inversely related to age and waist circumference, unrelated to serum testosterone or estradiol
Depression
- Testosterone had no impact on depression
Associations independent of treatment
- Reductions in waist circumference associated with improved erectile function; reductions in depression scores correlated with better sexual function
Clinically significant improvement in erectile function and sexual desire
- Erectile function
- 3%
- Sexual desire
- 10%
- Inversely related to baseline function; greater in younger (erectile function) and older (sexual desire) men
Original publication
Testosterone Treatment and Sexual Function in Men: Secondary Analysis of the T4DM (Testosterone for Diabetes) Trial. J Clin Endocrinol Metab. Published 10 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →