Testosterone Treatment, Weight Loss, and Health-related Quality of Life and Psychosocial Function in Men: A 2-year Randomized Controlled Trial
Authors' conclusion
In this diabetes prevention trial, weight loss induced by a lifestyle intervention improved HR-QOL and psychosocial function in more domains than testosterone treatment. The magnitude of weight and waist circumference reduction were predicted by baseline physical function, depressive symptomology, and sense of coherence.
Study context
- Population
- Men ≥50 years at high risk for T2D, without pathologic hypogonadism, 6 Australian centers648 with complete data
- Participants
- 1,007 men
- Comparison
- Testosterone undecanoate vs placebo on background lifestyle program
- Primary endpoint
- Self-reported measures of HR-QOL/psychosocial function
- Follow-up
- 2 years
Methodological detailsplacebo-controlled, multicentre, 2-year
- Placebo-controlled
- Multicentre
- 2-year
Primary result
As reported in the abstract
HR-QOL/psychosocial function · 24 months
- Most measures not different between treatment arms
- Testosterone vs placebo improved subjective social status and sense of coherence
Further findings
Baseline health-related quality of life (HR-QOL)/psychosocial function as predictor of testosterone effect on glycemic outcomes
- Baseline measures did not predict effect of testosterone on glycemic outcomes (T4DM primary endpoints)
Weight loss and HR-QOL/psychosocial function, irrespective of allocation
- Larger weight decreases associated with improved mental quality of life, mastery and subjective social status
Baseline predictors of weight loss
- Better baseline physical function, greater sense of coherence and fewer depressive symptoms associated with greater weight decreases; similar for waist circumference
Original publication
Testosterone Treatment, Weight Loss, and Health-related Quality of Life and Psychosocial Function in Men: A 2-year Randomized Controlled Trial. J Clin Endocrinol Metab. Published 9 February 2024. doi:10.
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