Circulating exosomal mir-16-2-3p is associated with coronary microvascular dysfunction in diabetes through regulating the fatty acid degradation of endothelial cells
Authors' conclusion
Our findings suggest that circulating miR-16-2-3p may serve as a biomarker for individuals with DM-CMD. Additionally, miR-16-2-3p appears to alleviate coronary microvascular dysfunction in diabetes by modulating ACADM-mediated fatty acid degradation in endothelial cells.
Study context
- Population
- Patients with diabetes mellitus (DM), DM with coronary microvascular dysfunction (DM-CMD) or DM with coronary artery disease (DM-CAD); high glucose-treated endothelial cells; db/db mice
- Outcome
- miR-16-2-3p expression and function
Main finding
As reported in the abstract
- miR-16-2-3p upregulated in circulating exosomes from DM-CMD, high glucose-treated human cardiac microvascular endothelial cells and hearts of db/db mice
- Cardiac miR-16-2-3p overexpression improved cardiac systolic and diastolic function and coronary microvascular reperfusion
- miR-16-2-3p could regulate fatty acid degradation in endothelial cells; ACADM identified as potential downstream target
- miR-16-2-3p increased cell migration and tube formation in microvascular endothelial cells
Original publication
Circulating exosomal mir-16-2-3p is associated with coronary microvascular dysfunction in diabetes through regulating the fatty acid degradation of endothelial cells. Cardiovasc Diabetol. Published 9 February 2024. doi:10.
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