Epicardial adipose tissue mediates the association between circulating hsa-miR-4750-3p and coronary artery disease in patients with type 2 diabetes mellitus
Authors' conclusion
These findings suggest that the proposed miRNA-EAT regulatory axis may be involved in the pathogenesis of diabetic atherosclerosis, with EAT appearing to partially mediate the relationship between hsa-miR-4750-3p and CAD. The integrated approach linking EAT and miRNAs holds potential for CAD risk stratification in T2DM.
Study context
- Population
- Patients with T2D and/or coronary artery disease (CAD) and healthy controls; Epicardial adipose tissue (EAT) thickness by transthoracic echocardiography, body composition by bioelectrical impedance76 patients + 18 controls
- Exposure
- T2D-CAD vs T2D vs healthy controls
- Controlsn = eighteenreference
- Outcome
- Whether EAT mediates the association between circulating hsa-miR-4505, hsa-miR-4743-5p, hsa-miR-4750-3p and CAD in T2D, and its diagnostic performance alone or combined
Methodological detailscausal mediation analysis, multivariate logistic regression, ROC analysis
- Causal mediation analysis
- Multivariate logistic regression
- ROC analysis
Main finding
As reported in the abstract
Mediation and diagnostic performance
- Proportion of total effect of hsa-miR-4750-3p on CAD in T2D mediated by EAT
- 48.79%
- hsa-miR-4750-3p as standalone predictor of EAT thickness after multivariable adjustment
- β = - 0.445, p = 0.003
- AUC for CAD detection in T2D: EAT + miRNAs
- 0.988
- AUC: EAT alone
- 0.869
- AUC: clinical factors
- 0.829
- AUC: EAT + clinical factors
- 0.901
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Median EAT thicknessT2DM-CAD vs T2DM · higher in T2DM-CAD vs T2DM and controls | P < 0.0001 |
Correlates of EAT thickness (bivariate)
- Positive correlation with TG concentration; negative correlation with hsa-miR-4750-3p expression
Independent associations with CAD risk in T2D (logistic regression)
- Enlarged EAT, up-regulated hsa-miR-4505 and hsa-miR-4743-5p, and down-regulated hsa-miR-4750-3p independently associated with higher CAD risk
Original publication
Epicardial adipose tissue mediates the association between circulating hsa-miR-4750-3p and coronary artery disease in patients with type 2 diabetes mellitus. Cardiovasc Diabetol. Published 15 January 2026. doi:10.
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