Epicardial adipose tissue thickness is associated with reduced peak oxygen consumption and systolic reserve in patients with type 2 diabetes and normal heart function
Authors' conclusion
Higher EAT thickness in T2D is associated with worse cardiopulmonary performance and multiple traits of subclinical cardiac systolic dysfunction.
Study context
- Population
- Patients with T2D and normal biventricular systo-diastolic function undergoing maximal cardiopulmonary exercise test with stress echocardiography
- Participants
- 72 patients
- Exposure
- Epicardial adipose tissue (EAT) thickness above vs below the median
- Outcome
- Cardiopulmonary performance (VO2peak)
Main finding
As reported in the abstract
VO2peak
P = 0.001
Observational data: associations, not effects.
Further findings
NT-proBNP · higher with higher EAT
P = 0.04
| Outcome | EAT > 5 mm | EAT ≤ 5 mm | P value |
|---|---|---|---|
| Systolic reserve (ΔS')Reduced with higher EAT | 4.6 ± 1.6 m/s | 5.8 ± 2.5 m/s | P = 0.02 |
Other cardiopulmonary measures
- Higher EAT associated with chronotropic insufficiency and impaired heart rate recovery
- Ventilatory variables and peripheral oxygen extraction not different between groups
- EAT negatively correlated with peak heart rate, heart rate recovery, workload, VO2 at anaerobic threshold and peak, and cardiac power output; directly correlated with natriuretic peptides
- EAT > 5 mm: higher body fat mass, smaller indexed LV dimensions, marginally reduced diastolic function at rest
Original publication
Epicardial adipose tissue thickness is associated with reduced peak oxygen consumption and systolic reserve in patients with type 2 diabetes and normal heart function. Diabetes Obes Metab. Published 27 September 2022. doi:10.
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