Incident heart failure, arrhythmias and cardiovascular outcomes with sodium‐glucose cotransporter 2 ( SGLT2 ) inhibitor use in patients with diabetes: Insights from a global federated electronic medical record database
Main finding · Incident HFResult — go to the resultHazard ratio 0.70 95% CI 0.68–0.73Authors' conclusion
Use of SGLT2 inhibitors was associated with a significant reduction in the risk of incident heart failure and adverse cardiovascular outcomes but not ventricular arrhythmias.
Study context
- Population
- All patients with diabetes registered January 2018–December 2019 in a federated electronic medical record database (TriNetX)131,188 per group after propensity-score matching (PSM)
- Participants
- 131,188 vs 131,188
- Exposure
- SGLT2i use vs no SGLT2i use
- SGLT2 inhibitorn = 131,188
- non-SGLT2 inhibitorn = 131,188reference
- Outcome
- Incident HF
- Follow-up
- 2 years
Methodological details1:1 propensity-score matched, federated electronic medical record database (TriNetX)
- 1:1 propensity-score matched
- Federated electronic medical record database (TriNetX)
Main finding
As reported in the abstract
Hazard ratio
0.70
95% CI 0.68–0.73
SGLT2ivs Non-SGLT2i
HR 0.70 (95% CI 0.68–0.73)
Observational data: associations, not effects.
Secondary outcomes
| Outcome | HR (95% CI) | |
|---|---|---|
| All-cause mortalitySGLT2ivs Non-SGLT2i | 0.61 (0.58–0.64) | |
| Cardiac arrestSGLT2ivs Non-SGLT2i | 0.70 (0.63–0.78) | |
| Incident AFSGLT2ivs Non-SGLT2i | 0.81 (0.76–0.84) | |
| Ischaemic stroke/TIASGLT2ivs Non-SGLT2i | 0.90 (0.88–0.93) | |
| Composite of arterial and venous thrombotic eventsSGLT2ivs Non-SGLT2i | 0.90 (0.88–0.92) | |
| Composite of incident VT/VF and cardiac arrestSGLT2ivs Non-SGLT2i | 0.76 (0.71–0.81) | |
| VT/VFSGLT2ivs Non-SGLT2i | 0.94 (0.88–1.00) | |
| 0.512Hazard ratio (log scale) |
Original publication
Incident heart failure, arrhythmias and cardiovascular outcomes with sodium‐glucose cotransporter 2 ( SGLT2 ) inhibitor use in patients with diabetes: Insights from a global federated electronic medical record database. Diabetes Obes Metab. Published 27 September 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →