A clinical prediction model for beta cell monogenetic diabetes in Chinese patients with early-onset type 2 diabetes
Authors' conclusion
We developed a clinical prediction model as a simple screening tool for multi-type beta-cell-MgD, identifying who are most likely to benefit from next genetic sequencing in Chinese population. PRS might be helpful for further screening of MgD.
Study context
- Population
- Chinese patients with early-onset T2D (EOD) and multi-type beta cell monogenetic diabetes (beta-cell-MgD)3 cohorts
- Comparison
- TyG-MgD score with or without polygenetic risk score (PRS) for identifying beta-cell-MgD
- Outcome
- Ability to identify beta-cell-MgD (AUC)
Methodological detailsprediction model development by logistic regression, external validation in independent cohorts
- Prediction model development by logistic regression
- External validation in independent cohorts
Performance
As reported in the abstract
Identification of beta-cell-MgD
| Test or model | AUC (Cohort 1) | AUC (validation cohorts) | AUC | Sensitivity at cutoff −16.19 | Specificity at cutoff −16.19 |
|---|---|---|---|---|---|
| TyG-MgD | 0.769 | 0.966 and 0.754 respectively | — not stated in the abstract | 66.3% | 75.39% |
| TyG-MgD + East Asian PRS | — not stated in the abstract | — not stated in the abstract | 0.842 | — not stated in the abstract | — not stated in the abstract |
| TyG-MgD + beta-cell dysfunction-high proinsulin PRS | — not stated in the abstract | — not stated in the abstract | 0.834 | — not stated in the abstract | — not stated in the abstract |
AUC (Cohort 1)
TyG-MgD0.769
TyG-MgD + East Asian PRS— not stated in the abstract
TyG-MgD + beta-cell dysfunction-high proinsulin PRS— not stated in the abstract
AUC (validation cohorts)
TyG-MgD0.966 and 0.754 respectively
TyG-MgD + East Asian PRS— not stated in the abstract
TyG-MgD + beta-cell dysfunction-high proinsulin PRS— not stated in the abstract
AUC
TyG-MgD— not stated in the abstract
TyG-MgD + East Asian PRS0.842
TyG-MgD + beta-cell dysfunction-high proinsulin PRS0.834
Sensitivity at cutoff −16.19
TyG-MgD66.3%
TyG-MgD + East Asian PRS— not stated in the abstract
TyG-MgD + beta-cell dysfunction-high proinsulin PRS— not stated in the abstract
Specificity at cutoff −16.19
TyG-MgD75.39%
TyG-MgD + East Asian PRS— not stated in the abstract
TyG-MgD + beta-cell dysfunction-high proinsulin PRS— not stated in the abstract
— not stated in the abstract
- At optimal cutoff, one beta-cell-MgD case identified among every three patients
- 1 in 3
- Screening threshold −16.85 prioritizing sensitivity
- 80% sensitivity, 59% specificity
Original publication
A clinical prediction model for beta cell monogenetic diabetes in Chinese patients with early-onset type 2 diabetes. Diabetes Metab. Published 15 January 2026. doi:10.
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