Higher Genetic Risk for Type 2 Diabetes Is Associated With a Faster Decline of β-Cell Function in an East Asian Population
Authors' conclusion
Individuals with a higher genetic risk for T2D exhibited not only a lower OGTT-derived β-cell function at baseline but also a notably more rapid decline during follow-up. This information could be used to enable a focused precision prevention with lifestyle intervention.
Study context
- Population
- Participants without T2D at baseline, community-based cohort in Korea; mean (SD) age 51.6 (8.7) years
- Participants
- 6,311 participants
- Exposure
- High vs intermediate vs low genetic risk for T2D
- Outcome
- Longitudinal change of β-cell function (OGTT-derived disposition index, DI)
- Follow-up
- 14 years
Methodological detailscommunity-based, biennial oral glucose tolerance tests (OGTTs) over 14 years
- Community-based
- Biennial OGTTs over 14 years
Main finding
As reported in the abstract
Longitudinal decline in log2-transformed OGTT-derived DI per year · mean follow-up 10.9 years
- Faster decline in log2-transformed disposition index (DI) per year (longitudinal analysis), P = 2.1 × 10-3
- 1.83-fold
- Per 1-SD increase in T2D polygenic risk score (PRS)
- P = 1.2 × 10-4
Observational data: associations, not effects.
Further findings
Incident T2D · mean follow-up 10.9 years
DI at baseline
- High vs low genetic risk: lower DI
- 25%
Lifestyle (Life's Essential 8) and DI decline
- Healthy lifestyle attenuated the rate of decline in DI across all genetic risk groups
Original publication
Higher Genetic Risk for Type 2 Diabetes Is Associated With a Faster Decline of β-Cell Function in an East Asian Population. Diabetes Care. Published 3 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →