Polygenic risk scores and lifestyle factors predicting new onset of type 2 diabetes in the Japanese general population
Authors' conclusion
PRS are associated with diabetes risk in Japanese general populations, independent of traditional risk factors.
Study context
- Population
- Japanese general population: Shika resident cohort (cross-sectional, n = 895) and Toshiba worker cohort (longitudinal, n = 7019); Polygenic risk scores (PRS) built from East Asian genome-wide association study datatwo cohorts
- Exposure
- High vs low polygenic risk score
- Outcome
- Diabetes (T2D) defined by HbA1c, fasting blood glucose, self-reported diagnosis or medication use
Methodological detailstwo cohorts, multivariate logistic regression, Cox proportional hazards models
- Two cohorts
- Multivariate logistic regression
- Cox proportional hazards models
Main finding
As reported in the abstract
Diabetes risk, high vs low PRS
High PRS vs Low PRSEstimate (95% CI)
Resident cohort
OR 4.51(2.53–8.04)
Worker cohort
HR 1.50(1.23–1.83)
Observational data: associations, not effects.
Further findings
Lifestyle factors and diabetes risk
- Regular exercise, absence of hypertension and absence of dyslipidemia associated with lower diabetes risk, particularly in the high PRS group
Risk prediction
- Adding PRS to conventional prediction models improved discrimination of diabetes risk
Original publication
Polygenic risk scores and lifestyle factors predicting new onset of type 2 diabetes in the Japanese general population. J Clin Endocrinol Metab. Published 16 April 2026. doi:10.
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