Nature vs nurture of glucose homeostasis trajectories in children from the Avon Longitudinal Study of Parents and Children (ALSPAC) study
Authors' conclusion
Genes interact with environment to define glucose homeostasis in youth
Study context
- Population
- Children and young adults aged 7–24 years from the Avon Longitudinal Study of Parents and Children (ALSPAC)
- Participants
- 8,783 children
- Exposure
- PRS-enhanced models vs environmental factors alone
- Outcome
- Prediction of glycaemic traits and gene-environment interactions
Methodological detailspolygenic risk scores, gene-environment interaction analysis, pathway-specific PRSs
- Polygenic risk scores
- Gene-environment interaction analysis
- Pathway-specific PRSs
Main finding
As reported in the abstract
Prediabetes prevalence at age 24 years (up to)
24%
AUC for dysglycaemia at age 15, PRS-enhanced model (improved by 0.12 vs environmental factors alone)
0.78
Fasting glucose PRS: AUC differentiating transient from persistent prediabetes
0.70
Observational data: associations, not effects.
Original publication
Nature vs nurture of glucose homeostasis trajectories in children from the ALSPAC study. Diabetologia. Published 15 April 2026. doi:10.
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