Concurrent training is associated with enhanced post-exercise ceramide clearance and fat oxidation capacity in individuals with type 2 diabetes following lifestyle intervention
Authors' conclusion
Concurrent training during PD-induced weight loss improves cardiometabolic fitness and is associated with an enhanced ability to clear bioactive sphingomyelins and ceramides from the circulation in the recovery phase after an exercise test.
Study context
- Population
- Individuals with overweight or obesity who had T2Dlipidomics subgroup n=21
- Participants
- 27 individuals
- Comparison
- Palaeolithic-type diet plus concurrent exercise training (PD+E) vs palaeolithic-type diet alone (PD)
Methodological detailssubgroup with plasma lipidomics, supervised exercise training
- Subgroup with plasma lipidomics
- Supervised exercise training
Primary result
As reported in the abstract
Physiological responses and circulating lipid dynamics during exercise and recovery · 12 weeks
- Glycaemic management during and after the exercise test improved similarly in both groups
- Only PD+E showed improvements in cardiometabolic fitness
- Resting triacylglycerols reduced in both groups; additional reductions of very-long-chain ceramides (>C22 acyl chains) in PD+E
- Sphingomyelins and ceramides increased during exercise in both groups; only PD+E improved their clearance during recovery
- Lipid response during recovery associated with improvements in fat oxidation during exercise
Original publication
Concurrent training is associated with enhanced post-exercise ceramide clearance and fat oxidation capacity in individuals with type 2 diabetes following lifestyle intervention. Diabetologia. Published 5 August 2026. doi:10.
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