Aerobic Exercise Training Increases Circulating sRAGE in Adults With Type 2 Diabetes: Associations With Sheddase Regulation
Authors' conclusion
AET increased circulating sRAGE and improved select metabolic health outcomes in adults with T2DM.
Study context
- Population
- Sedentary adults with T2D
- Participants
- 33 adults
- Comparison
- Supervised aerobic exercise training vs standard of care control
- Aerobic exercise training (AET)n = 20
- Control (CON)n = 13reference
Methodological detailssupervised aerobic exercise training
- Supervised aerobic exercise training
Primary result
As reported in the abstract
12 weeks
- AET increased circulating sRAGE concentrations across the intervention period
- sTLR4 was unchanged
Further findings
Metabolic and fitness outcomes
- AET improved cardiorespiratory fitness, reduced body fat percentage and fat mass, lowered fructosamine and increased the Matsuda Index
Skeletal muscle inflammatory signalling
- Significant alterations in selected TIMP:MMP and TIMP:ADAM10 ratios; no changes in ADAM10 activity or skeletal muscle RAGE protein expression
Exploratory: change in sRAGE vs aerobic fitness
- Associations between changes in circulating sRAGE and aerobic fitness
- Exploratory analyses
Original publication
Aerobic Exercise Training Increases Circulating sRAGE in Adults With Type 2 Diabetes: Associations With Sheddase Regulation. Diabetes Obes Metab. Published 17 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →