Metformin attenuates metabolic insulin sensitivity and insulin‐stimulated carbohydrate oxidation after high‐intensity exercise training in adults at risk for metabolic syndrome
Authors' conclusion
Metformin attenuated metabolic insulin sensitivity and insulin-stimulated carbohydrate oxidation after high-intensity exercise training in adults at risk for MetS.
Study context
- Population
- Adults at risk for metabolic syndrome (MetS)
- Participants
- 22 / 21 / 24 / 24
- Comparison
- Low- or high-intensity exercise plus metformin vs plus placebo
- LoEx + PLn = 22reference
- LoEx + Metn = 21
- HiEx + PLn = 24
- HiEx + Metn = 24
- Primary endpoint
- Metabolic insulin sensitivity (M-value/insulin) by 120-min euglycaemic-hyperinsulinemic clamp
- Follow-up
- 16 weeks
Methodological detailsdouble-blind, placebo-controlled
- Double-blind
- Placebo-controlled
Primary result
As reported in the abstract
Metabolic insulin sensitivity
- HiEx + PL increased metabolic insulin sensitivity
- p = 0.017
Further findings
| Outcome | P value |
|---|---|
| Insulin-stimulated carbohydrate oxidation and fat oxidationHiEx + PL vs LoEx + Met | P = 0.008 |
- Insulin-stimulated carbohydrate oxidation and fat oxidation: raised carbohydrate oxidation and decreased fat oxidation with HiEx + PL (both)
Correlates of increased metabolic insulin sensitivity after exercise and placebo
- Reduction in fasting glucose
- r = −0.41, p = 0.025
- VO2max
- r = 0.55, p = 0.002
- Reduction in fasting leptin
- r = −0.54, p = 0.01
- Weight loss
- r = −0.60, p < 0.001
- Not related after exercise and metformin
Original publication
Metformin attenuates metabolic insulin sensitivity and insulin‐stimulated carbohydrate oxidation after high‐intensity exercise training in adults at risk for metabolic syndrome. Diabetes Obes Metab. Published 14 January 2026. doi:10.
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