High-intensity interval training improves insulin sensitivity in individuals with prediabetes
Authors' conclusion
Twelve weeks of low-volume HIIT training can improve glucose control and induces adaptations in skeletal muscle important for metabolic health in individuals with prediabetes.
Study context
- Population
- Sedentary individuals with prediabetes; women n = 36; age 60.8 ± 11.3 years; BMI 31.6 ± 4.4 kg/m²; FPG 6.6 ± 0.8 mmol/L; HbA1c 5.7 ± 0.4%
- Participants
- 70 individuals
- Comparison
- Low-volume high-intensity interval training (HIIT), HIIT + walking, or walking vs no training
- Primary endpoint
- Insulin sensitivity assessed by OGTT
- Follow-up
- 12 weeks
Methodological details4-arm
- 4-arm
Primary result
As reported in the abstract
Peripheral insulin sensitivity (Cederholm index)
Each group vs controlETD, % (95% CI)
HIITsignificantly improved
18.5(7.4–28.3)
HIIT + walkingsignificantly improved
15.7(4.4–25.6)
Walking
9.4(−2.5 to 19.9)
Further findings
| Outcome | ETD (%) (95% CI) | |
|---|---|---|
| Whole-body insulin sensitivity (Matsuda index) · 12 weeksHIIT + walkingvs Control | 28.0 (10.3–42.3) | |
| Whole-body insulin sensitivity (Matsuda index) · 12 weeksWalkingvs Control | 42.3 (28.3–53.5) | |
| Whole-body insulin sensitivity (Matsuda index) · 12 weeksHIITvs Control | 17.0 (−4.0 to 33.7) | |
| −50050100Difference, % (linear scale) |
Skeletal muscle proteins for mitochondrial capacity and glucose uptake
- Most improved with HIIT + walking; no significant effects with walking alone
Original publication
High-intensity interval training improves insulin sensitivity in individuals with prediabetes. Eur J Endocrinol. Published 16 April 2025. doi:10.
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