Metformin Blunts Vascular Insulin Sensitivity After Exercise Training in Adults at Risk for Metabolic Syndrome
Authors' conclusion
Met blunts exercise training-mediated increases in vascular insulin sensitivity at the levels of conduit arteries and capillaries, in parallel with altered inflammation and glycemic benefits.
Study context
- Population
- Adults at risk for metabolic syndrome
- Participants
- 22 / 21 / 24 / 24
- Comparison
- Metformin vs placebo with low- or high-intensity exercise training for 16 weeks
- LoEx + PLn = 22reference
- LoEx + metformin (Met)n = 21
- HiEx + PLn = 24reference
- HiEx + Metn = 24
- Primary endpoint
- Vascular insulin sensitivity during euglycemic-hyperinsulinemic clamp: macrovascular (brachial artery %FMD) and microvascular (contrast-enhanced US: MBV, MBF)
- Follow-up
- Pre and post 16 weeks
Methodological detailsdouble-blind, placebo-controlled
- Double-blind
- Placebo-controlled
Primary result
As reported in the abstract
Insulin-stimulated FMDallometric and MBF · 16 weeks
- Met blunted the increase in insulin-stimulated FMDallometric and MBF seen with LoEx + PL and HiEx + PL
- P < .05
Further findings
VO2max · 16 weeks
- Increased with LoEx + PL and HiEx + PL
- both P < .05
- No change with LoEx + Met or HiEx + Met
Body fat · 16 weeks
- Reduced following HiEx + PL and HiEx + Met only
- both P < .05
Fasting glucose, ET-1 and TNF-α · 16 weeks
- Met attenuated the reductions vs LoEx + PL and HiEx + PL
- P < 0.05
Original publication
Metformin Blunts Vascular Insulin Sensitivity After Exercise Training in Adults at Risk for Metabolic Syndrome. J Clin Endocrinol Metab. Published 7 October 2025. doi:10.
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