Association between circulating levels of unsaturated fatty acids and risk for prediabetes in the NHANES 2003–2004 and 2011–2012
Authors' conclusion
Some serum n-3 PUFAs are positively associated with prediabetes, several serum n-6 PUFAs are inversely associated with prediabetes. Regulating individual serum USFA levels may help prevent prediabetes, thereby providing evidence for clinical and nutritional practices.
Study context
- Population
- Participants of the National Health and Nutrition Examination Survey 2003–2004 and 2011–2012
- Participants
- 3,575 participants
- Exposure
- Serum levels of PUFAs and MUFAs and prediabetes risk
- Outcome
- Prediabetes risk
Methodological detailsNHANES 2003–2004 and 2011–2012, weighted proportional and multivariate logistic regression, adjusted for potential confounders
- NHANES 2003–2004 and 2011–2012
- Weighted proportional and multivariate logistic regression
- Adjusted for potential confounders
Main finding
As reported in the abstract
Prediabetes risk by serum unsaturated fatty acid levels
Estimate (95% CI)P value
EPA (20:5 n3)PUFA; increased prediabetes risk
OR 1.878(1.177–2.996)
P = 0.002for trendGLA (18:3 n6)PUFA; increased prediabetes risk
OR 1.702(1.140–2.541)
P = 0.016for trendPA (16:1 n7)MUFA
OR in quintile5 1.780(1.056–3.001)
P = 0.003for trendEA (20:1 n9)MUFA
OR in quintile5 0.587(0.347–0.994)
P = 0.010for trendObservational data: associations, not effects.
Further findings
Nonlinear association with prediabetes risk
- Serum EPA (20:5 n3) and EA (20:1 n-9) were nonlinearly associated with prediabetes risk
Original publication
Association between circulating levels of unsaturated fatty acids and risk for prediabetes in the NHANES 2003–2004 and 2011–2012. Diabetes Res Clin Pract. Published 3 June 2024. doi:10.
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