Effects of Obesity and Hyperglycemia on Postprandial Insulin-Mediated and Non–Insulin-Mediated Glucose Disposal
Authors' conclusion
NIMGD is a major mechanism of postprandial TGD in people with insulin resistance and inadequate insulin secretion.
Study context
- Population
- People with obesity and different glycemic status, and lean people with normal glucose tolerance (NGT)
- Comparison
- Lean NGT vs Ob-NGT vs Ob-IGT vs Ob-T2D; Intensive lifestyle therapy (ILT) in obesity with T2D
- Outcome
- Total, insulin-mediated and non-insulin-mediated glucose disposal (TGD, IMGD, NIMGD) after glucose ingestion
Methodological detailsglucose tracer model with OGTT, intervention substudy of intensive lifestyle therapy
- Glucose tracer model with OGTT
- Intervention substudy of intensive lifestyle therapy
Main finding
As reported in the abstract
| Group | IMGD share of TGD | NIMGD share of TGD |
|---|---|---|
| Lean | about 70% | ∼40% |
| Ob-NGT | 65% | 35% |
| Ob-IGT | 50% | 50% |
| Ob-T2D | 20% | 80% |
IMGD share of TGD
Leanabout 70%
Ob-NGT65%
Ob-IGT50%
Ob-T2D20%
NIMGD share of TGD
Lean∼40%
Ob-NGT35%
Ob-IGT50%
Ob-T2D80%
Further findings
Effect of ILT (∼15% weight loss) in obesity with T2D
- ILT increased IMGD and decreased NIMGD
Original publication
Effects of Obesity and Hyperglycemia on Postprandial Insulin-Mediated and Non–Insulin-Mediated Glucose Disposal. Diabetes Care. Published 5 November 2024. doi:10.
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