Impaired plasma glucose clearance is a key determinant of fasting hyperglycemia in people with obesity
Authors' conclusion
Fasting hyperglycemia in people with obesity represents a disruption of the precisely regulated integration of glucose production and clearance rates.
Study context
- Population
- Lean people and people with obesity with different fasting glycaemic statuses206 with obesity
- Participants
- 33 / 118 / 66 / 22
- Comparison
- Lean normoglycaemic vs obese with normal, impaired or diabetic fasting glucose
- Lean < 100n = 33reference
- Ob < 100n = 118
- Ob 100-125n = 66
- Ob ≥ 126n = 22
- Outcome
- Relative importance of basal glucose Ra and basal plasma glucose clearance in determining fasting plasma glucose
Main finding
As reported in the abstract
Basal glucose kinetics
- Large (up to three-fold) range in glucose Ra within each group; small glucose ranges in Lean < 100, Ob < 100 and Ob 100-125 due to close relationship between glucose Ra and clearance rate
- Glucose clearance rate at any Ra value lower in hyperglycaemic than normoglycaemic groups
- In Ob ≥ 126, plasma glucose primarily determined by glucose Ra, as glucose clearance markedly attenuated
Original publication
Impaired plasma glucose clearance is a key determinant of fasting hyperglycemia in people with obesity. Obesity (Silver Spring). Published 16 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →