Impaired Suppression of Plasma Lipid Extraction and Its Partitioning Away From Muscle by Insulin in Humans With Obesity
Authors' conclusion
Partitioning of circulating lipids away from the skeletal muscle when plasma insulin increases during the postprandial period is impaired in humans with obesity and insulin resistance.
Study context
- Population
- Humans studied in a postprandial state with steady-state plasma TG concentrations; forearm muscle
- Comparison
- Lean, insulin-sensitive vs obese, insulin-resistant humans: muscle lipid extraction before vs after insulin infusion
- Outcome
- Insulin modulation of muscle extraction of circulating TGs and NEFAs of ingested and endogenous origin
Methodological detailsarterio-venous blood sampling, stable isotope-labeled triolein
- Arterio-venous blood sampling
- Stable isotope-labeled triolein
Main finding
As reported in the abstract
- Lean-IS: insulin rapidly suppressed extraction of plasma triglycerides (TGs) of endogenous but not ingested origin
- Obese-IR: suppression of endogenous TG extraction by insulin absent
- Lean-IS: insulin decreased extraction of circulating nonesterified fatty acids (NEFAs) of both ingested and endogenous origin
- Obese-IR: decrease absent for NEFAs of ingested origin
Original publication
Impaired Suppression of Plasma Lipid Extraction and Its Partitioning Away From Muscle by Insulin in Humans With Obesity. J Clin Endocrinol Metab. Published 14 October 2024. doi:10.
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