Comparison of Metabolic Response to Colonic Fermentation in Lean Youth vs Youth With Obesity
Authors' conclusion
In this cross-sectional study, lean, OIS, and OIR youth demonstrated different associations between colonic fermentation of indigestible dietary carbohydrates and the metabolic response, with OIR youth showing minimal metabolic modifications as compared with the other 2 groups.
Study context
- Population
- Youths aged 15 to 22 years with BMI in the 25th to 75th percentile or >85th percentile for age and sex, New Haven County, Connecticut; 20 g lactulose during 10-hour sodium d3-acetate IV infusion
- Participants
- 44 participants
- Exposure
- Lean vs obese insulin sensitive vs obese insulin resistant youth
- Outcome
- Hourly plasma acetate turnover, PYY, ghrelin, active GLP-1 and FFA
Main finding
As reported in the abstract
Rate of acetate appearance
Lean vs obese insulin resistant (OIR): lean vs OIR P = .004 · obese insulin sensitive (OIS) vs OIR: OIS vs OIR P = .09
Observational data: associations, not effects.
Further findings
PYY response — Lean vs OIR
lean vs OIR P = .002
Median
| Outcome | Lean | OIS | OIR | P value |
|---|---|---|---|---|
| Improvement of adipose insulin sensitivity indexLean vs OIR | 0.277 (IQR 0.220–0.446) | 0.340 (IQR 0.048–0.491) | 0.043 (IQR 0.006–0.155) | lean vs OIR P = .002 |
| Improvement of adipose insulin sensitivity indexOIS vs OIR | OIS vs OIR P = .08 | |||
| PYY responseOIS vs OIR | OIS vs OIR P = .011 |
Original publication
Comparison of Metabolic Response to Colonic Fermentation in Lean Youth vs Youth With Obesity. JAMA Netw Open. Published 1 May 2023. doi:10.
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