Factors Associated With Cognitive Improvement After Bariatric Surgery Among Patients With Severe Obesity in the Netherlands
Authors' conclusion
This study suggests that lower C-reactive protein and leptin levels, as well as fewer depressive symptoms, might partly explain the mechanisms behind cognitive improvement after bariatric surgery.
Study context
- Population
- Patients aged 35–55 years with severe obesity (BMI >35) eligible for RYGB, BARICO study, Netherlands, 2018–2020; mean (SD) age 46.1 (5.7) years, 84.9% women146 analysed
- Participants
- 156 patients
- Exposure
- Cognitive improvement vs no cognitive improvement after RYGB
- Cognitive improvementn = 57
- Outcome
- Overall cognitive performance (20% change index of compound z score); inflammatory factors, adipokines, mood (Beck Depression Inventory), physical activity (Baecke)
- Follow-up
- 6 months
Methodological detailsBARICO study
- BARICO study
Main finding
As reported in the abstract
Cognitive improvement
Cognitive improvement overall
43.8%
57 of 130
Observational data: associations, not effects.
Further findings
C-reactive protein · 6 months · lower with cognitive improvement
P = 0.04
Leptin · 6 months · lower with cognitive improvement
P = 0.04
| Outcome | Cognitive improvement | No cognitive improvement | P value |
|---|---|---|---|
| Depressive symptoms (Beck Depression Inventory) · 6 monthsFewer with cognitive improvement | 4 | 5 | P = 0.045 |
Changes after surgery (all participants) · 6 months
- C-reactive protein, median change
- −0.32 mg/dL (IQR, −0.57 to −0.16 mg/dL); P < .001
- Leptin, median change
- −51.5 pg/mL (IQR, −68.0 to −38.4 pg/mL); P < .001
- Adiponectin, median change
- 0.15 μg/mL (IQR, −0.20 to 0.62 µg/mL); P < .001
- Beck Depression Inventory score, median change
- −3 (IQR, −6 to 0); P < .001
- Baecke score, mean (SD) change
- 0.7 (1.1); P < .001
Original publication
Factors Associated With Cognitive Improvement After Bariatric Surgery Among Patients With Severe Obesity in the Netherlands. JAMA Netw Open. Published 1 May 2023. doi:10.
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