Association of abdominal adiposity, hepatic shear stiffness with subclinical left-ventricular remodeling evaluated by magnetic resonance in adults free of overt cardiovascular diseases: a prospective study
Authors' conclusion
Ectopic fat depositions in the liver and pancreas, and excess abdominal adipose tissue pose a risk of subclinical LV remodeling beyond MetS-related CVD risk factors in adults without overt CVD. VAT may play a more considerable role as a risk factor for subclinical LV dysfunction than does SAT in individuals with obesity. The underlying mechanisms of these associations and their longitudinal clinical implications need further investigation.
Study context
- Population
- Adults free of overt cardiovascular disease (CVD) (subjects with obesity and healthy controls) undergoing 3 T cardiac and body magnetic resonance (MR)
- Participants
- 88 adults
- Exposure
- Associations of MR-based abdominal adiposity and hepatic shear stiffness with subclinical left ventricular (LV) remodeling
- Obesityn = 46
- Healthy controlsn = 42reference
- Outcome
- Associations of H-PDFF, P-PDFF, hepatic shear stiffness (MR elastography), SAT and VAT with EAT and LV geometry and function, adjusted for age, sex and MetS-related confounders
Methodological detailsexploratory, 3 T cardiac and body MR
- Exploratory
- 3 T cardiac and body MR
Main finding
As reported in the abstract
- Higher H-PDFF, P-PDFF, SAT and VAT independently associated with lower LV global myocardial strain parameters (radial, circumferential and longitudinal PS, longitudinal peak systolic strain rate and diastolic strain rate)
- β = - 0.001 to - 0.41, p < 0.05
- P-PDFF, SAT and VAT independently and positively associated with LV end-diastolic volume and stroke volume
- β = 0.09 to 3.08, p ≤ 0.02
- No independent correlation between hepatic shear stiffness and epicardial adipose tissue (EAT) or LV remodeling
- all p ≥ 0.05
Observational data: associations, not effects.
Further findings
Obesity subgroup: association of P-PDFF and VAT with LV strain
- Higher P-PDFF and VAT independently associated with lower circumferential and longitudinal PS, respectively
- β = - 0.29 to - 0.05, p ≤ 0.01
Original publication
Association of abdominal adiposity, hepatic shear stiffness with subclinical left-ventricular remodeling evaluated by magnetic resonance in adults free of overt cardiovascular diseases: a prospective study. Cardiovasc Diabetol. Published 29 April 2023. doi:10.
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