The effect of hyperlipidemia and body fat distribution on subclinical left ventricular function in obesity: a cardiovascular magnetic resonance study
Authors' conclusion
Hyperlipidemia is independently associated with subclinical LV diastolic dysfunction in obesity. Central fat distribution (android and visceral fat) has a negative association, while peripheral fat distribution (gynoid fat) has a positive association on subclinical LV function. These results suggest that appropriate management of hyperlipidemia may be beneficial for obese patients, and that the differentiation of fat distribution in different regions may facilitate the precise management of obese patients. Clinical trials registration Effect of lifestyle intervention on metabolism of obese patients based on smart phone software
Study context
- Population
- Adults with obesity, with or without hyperlipidemia, and controls
- Participants
- 92 adults
- Exposure
- Obesity with hyperlipidemia vs obesity without hyperlipidemia vs controls
- Obesity with hyperlipidemian = 24
- Obesity without hyperlipidemian = 25
- Controlsn = 43reference
- Outcome
- Subclinical LV function: LV strain parameters (PS, PDSR, peak systolic strain rate) by cardiovascular magnetic resonance tissue tracking
Methodological detailscardiovascular magnetic resonance tissue tracking, DXA body fat distribution, multivariable linear regression
- Cardiovascular magnetic resonance tissue tracking
- DXA body fat distribution
- Multivariable linear regression
Main finding
As reported in the abstract
- Lower longitudinal peak strain (PS) with hyperlipidemia
- Obesity with hyperlipidemia vs Obesity without hyperlipidemia: all P < 0.05
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Global LV longitudinal PS (obesity with vs without hyperlipidemia)Lower with hyperlipidemia | all P < 0.05 |
| Global LV longitudinal PDSR (obesity with vs without hyperlipidemia)Lower with hyperlipidemia | all P < 0.05 |
| Global LV circumferential PDSR (obesity with vs without hyperlipidemia)Lower with hyperlipidemia | all P < 0.05 |
Left ventricular (LV) strain in obesity vs controls
- Obese individuals with preserved LV ejection fraction had lower global LV longitudinal, circumferential and radial PS and longitudinal and circumferential peak diastolic strain rate (PDSR) than controls (all P < 0.05)
Body fat distribution and LV strain (multivariable linear regression)
- Android fat vs longitudinal PS, β
- - 0.486
- Android fat vs radial PS, β
- - 0.408
- Visceral fat vs longitudinal PDSR, β
- - 0.563
- Gynoid fat vs circumferential PS, β
- 0.490
- Gynoid fat vs circumferential PDSR, β
- 0.481
- Gynoid fat vs radial PDSR, β
- 0.413
- All P < 0.05
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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