Obesity

The effect of GLP-1 receptor agonist use on negative evaluations of women with higher and lower body weight

Int J Obes (Lond)Published Randomised experimental study

Authors' conclusion

This timely study provides evidence that people with larger and smaller bodies alike are at-risk for being judged for using GLP-1 RAs due to beliefs that these medications are a shortcut. Findings also demonstrate novel reactions related to egotism when weight loss is achieved with pharmacological interventions. PRE-REGISTRATION AND DATA: osf.io/xme4w.

Study context

Population
U.S. adults (Mage = 37.8, SD = 13) reading about a woman who lost weightrandomly assigned
Participants
357 adults
Comparison
Weight loss with GLP-1 RA vs diet/exercise, in a lean woman vs a woman with obesity
Primary endpoint
Endorsement of negative weight-related stereotypes and egocentric attitudes toward the woman
Methodological details2 × 2 experimental design, pre-registered
  • 2 × 2 experimental design
  • Pre-registered

Primary result

As reported in the abstract

Negative evaluations and egocentric impressions
  • Negative evaluations and egocentric impressions stronger toward a woman who lost weight with a GLP-1 RA vs diet/exercise

Further findings

Mediation via weight loss shortcut beliefs

GLP-1 RA led to stronger negative evaluations through higher shortcut beliefs irrespective of body size
GLP-1 RA led to higher egocentric impressions through higher shortcut beliefs; effect stronger for a lean woman

Mediation via biogenetic causal beliefs

GLP-1 RA led to more negative evaluations through stronger biogenetic causal beliefs for a lean woman only

Original publication

The effect of GLP-1 receptor agonist use on negative evaluations of women with higher and lower body weight. Int J Obes (Lond). Published 1 April 2024. doi:10.1038/s41366-024-01516-4

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