Association of body-mass index with physiological brain pulsations across adulthood – a fast fMRI study
Authors' conclusion
The findings suggest that BMI is a significant factor in alterations of cardiovascular pulsation of neurofluids. As physiological pulsations are the drivers of CSF flow and subsequent metabolite clearance, these results emphasize the need for further research into the mechanisms through which obesity affects brain clearance.
Study context
- Population
- Healthy subjects across adulthood
- Participants
- 115 subjects
- Outcome
- Voxel-wise whole-brain association of BMI with amplitudes of very low frequency (VLF) (vasomotor), respiratory, cardiovascular and respiratory induced modulation of cardiovascular brain pulsations, adjusted for age, pulse pressure and gender
Methodological detailsresting-state fMRI, high temporal resolution whole-brain magnetic resonance encephalography (MREG), voxel-wise multiple linear regression
- Resting-state fMRI
- High temporal resolution whole-brain MREG
- Voxel-wise multiple linear regression
Main finding
As reported in the abstract
Association of BMI with physiological brain pulsation amplitudes
- Body-mass index (BMI) positively associated with amplitudes of vasomotor, respiratory and respiratory induced modulations of cardiovascular pulsations
- p < 0.05
- BMI negatively associated with amplitudes of cardiovascular pulsations
- p < 0.05
Observational data: associations, not effects.
Original publication
Association of body-mass index with physiological brain pulsations across adulthood – a fast fMRI study. Int J Obes (Lond). Published 29 March 2024. doi:10.
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