Exploring the link between inflammation and brain function after metabolic‐bariatric surgery: A year‐long fMRI study
Authors' conclusion
Our study is the first to identify brain regions significantly linked to inflammation after MBS. Importantly, many of the discovered areas were previously shown to be involved in the pathogenesis of obesity or are targets of contemporary medical treatments. Consequently, our findings offer valuable insights for future obesity research, especially in the context of potential therapeutic opportunities.
Study context
- Population
- Patients undergoing laparoscopic sleeve gastrectomy, examined 1 week before and 3 and 12 months after surgery
- Participants
- 36 patients
- Outcome
- Association of perioperative IL-6/IL-10 ratio with ALFF and functional connectivity across 375 brain regions
- Follow-up
- 1 week before, and 3 and 12 months after surgery
Methodological detailslongitudinal, fMRI, 3 time points
- Longitudinal
- fMRI
- 3 time points
Main finding
As reported in the abstract
Brain regions linked with IL-6/IL-10 ratio
- IL-6/IL-10 ratio increased early postoperatively, then decreased below preoperative levels at 1 year
- Amplitude of low-frequency fluctuation (ALFF) in 4 subcortical structures decreased with rising and increased with declining IL-6/IL-10 ratio
- 16 cortical regions showed the opposite ALFF trend
- Functional connectivity between left insula and bilateral medial prefrontal cortex increased with rising and decreased with declining ratio
Original publication
Exploring the link between inflammation and brain function after metabolic‐bariatric surgery: A year‐long fMRI study. Diabetes Obes Metab. Published 16 January 2025. doi:10.
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