Beyond weight loss: exploring bile acid modulations after bariatric surgery and their impact on type 2 diabetes across 5 years
Authors' conclusion
Although total BA levels return to baseline by 5 years after surgery, specific BA profiles, as identified by principal component analysis from oral glucose tolerance test data, are associated with sustained metabolic improvements. SR-LRYGB is associated with more durable metabolic benefits compared with LSG. However, given the use of the oral glucose tolerance test, which may not fully capture postprandial BA dynamics, further research using mixed-meal tolerance tests is needed to confirm these findings.
Study context
- Population
- Patients with obesity and T2D undergoing bariatric surgery
- Exposure
- SR-LRYGB vs laparoscopic sleeve gastrectomy (LSG)
- Outcome
- BA levels
- Follow-up
- 5 years
Main finding
As reported in the abstract
- Despite significant increases in the first year after surgery, BA levels returned to baseline after 5 years
- Principal component analysis: certain BA profiles may contribute to long-term metabolic benefits
Observational data: associations, not effects.
Original publication
Beyond weight loss: exploring bile acid modulations after bariatric surgery and their impact on type 2 diabetes across 5 years. Obesity (Silver Spring). Published 15 June 2025. doi:10.
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