Adolescent obesity and risk of serious chronic morbidity and mortality in young adulthood: a systematic review of cohorts from national registries
Authors' conclusion
Adolescent obesity is strongly associated with an elevated hazard for severe disease morbidity and mortality beginning in young adulthood, with associations progressing with obesity severity and time. The findings of this study demonstrate the need for public health mitigation and preventive strategies, which may yield substantial short, and long-term health benefits in this population.
Study context
- Population
- Adolescents with overweight or obesity followed into young adulthood and midlife, nationwide registry cohorts38 studies
- Comparison
- Adolescent overweight, obesity and severe obesity vs normal weight
- Outcome
- Short- and long-term risk of morbidity and mortality
Methodological detailsvalidated national registries
- Validated national registries
Pooled result
As reported in the abstract
Serious morbidity, T2D and T1D · <4 years of follow-up, before age 25 years
- Severe adolescent obesity: serious morbidity, men (HR)
- 5.1
- Severe adolescent obesity: serious morbidity, women (HR)
- 7.3
- Severe adolescent obesity: T2D, men (HR)
- 27.0
- Severe adolescent obesity: T2D, women (HR)
- 45.3
- Adolescent obesity: T1D (HR)
- 2.0
Further pooled results
Later-onset outcomes · before age 30, 40 and 50 years
- Before age 30: severe obesity associated with chronic kidney disease (CKD); obesity with colorectal cancer and cardiovascular disease (CVD) mortality
- Before age 40: overweight and obesity associated with ischemic stroke
- Before age 50: severe obesity associated with all-cause mortality; obesity with diabetes mortality and cancer
Original publication
Adolescent obesity and risk of serious chronic morbidity and mortality in young adulthood: a systematic review of cohorts from national registries. Cardiovasc Diabetol. Published 3 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →