Abnormal Bone Turnover Observed in Obese Children based on Puberty Stage–Specific Bone Turnover Marker Reference
Authors' conclusion
We provide age-, sex-, and puberty stage-specific P1NP and β-CTX reference curves. According to these, obesity appeared to be a negative factor for bone formation in boys and for bone resorption in girls.
Study context
- Population
- Chinese children and adolescents aged 6∼18 years, Evaluation and Monitoring on School-based Nutrition and Growth in Shenzhen study; 800 with normal body mass index (BMI) used for P1NP and β-CTX reference curves800 reference, 200 obese
- Exposure
- Obese vs normal-BMI matched children
- Obesen = 200
- Outcome
- Age-, sex- and puberty stage-specific BTM (P1NP, β-CTX) reference curves; effect of obesity on bone metabolism
Methodological detailsreference-curve study, 1:1 matched comparison
- Reference-curve study
- 1:1 matched comparison
Main finding
As reported in the abstract
- BTM values differed significantly by age, sex and puberty stage
- Low-level P1NP in girls: no significant difference
- High β-CTX in boys: not higher with obesity
- Obese vs Healthy: P = 0.005
- Obese vs Healthy: P = 0.022
Observational data: associations, not effects.
Original publication
Abnormal Bone Turnover Observed in Obese Children based on Puberty Stage–Specific Bone Turnover Marker Reference. J Clin Endocrinol Metab. Published 1 April 2024. doi:10.
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