Plasma pentraxin‐3 levels and its role in childhood obesity—Is it anti‐inflammatory? A matched group study
Authors' conclusion
There was an indirect relationship between the amount of subcutaneous adipose tissue and PTX-3 level. The results of our study suggested that plasma PTX-3 was associated with lower levels of inflammation in children.
Study context
- Population
- Children aged 6–17 years; mean age 12.34 ± 2.86 years
- Participants
- 91 children
- Comparison
- Obese vs non-obese children
- Outcome
- Plasma PTX-3 levels
Main finding
As reported in the abstract
- Plasma PTX-3 levels significantly higher in obese children
- Obese vs Non-obese: P = 0.028
Further findings
Correlation of BMI SDS with plasma PTX-3
- Weak positive correlation when physical activity level controlled
- r = .176, p = .049
- No significant correlation between BMI SDS and plasma PTX-3
Fat mass and subcutaneous adipose tissue
- Fat mass was a partial mediator of plasma PTX-3; increased subcutaneous adipose tissue negatively affected plasma PTX-3
Correlates of plasma PTX-3
- Weak positive correlation with physical activity score and dietary polyunsaturated fatty acid intake
- r = .223, p = .017
- Increase in plasma PTX-3 per one-unit increase in physical activity score
- 0.730 unit
- Increase in plasma PTX-3 per one-unit increase in polyunsaturated fatty acid level
- 2.061 unit
- Decrease in plasma PTX-3 per one-unit increase in dietary fat intake
- 0.413-unit
- Weak negative correlation with neutrophil-to-lymphocyte ratio
Original publication
Plasma pentraxin‐3 levels and its role in childhood obesity—Is it anti‐inflammatory? A matched group study. Clin Endocrinol (Oxf). Published 1 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →