Insulin resistance modulates gut microbiota and incretin response remodeling after bariatric surgery in severe obesity
Authors' conclusion
These findings underscore the role of GM in metabolic changes and surgical outcomes after SG. Targeting gut microbiota may offer a promising avenue for improving obesity treatment strategies.
Study context
- Population
- Patients with severe obesity and normal glucose tolerance undergoing sleeve gastrectomy (SG); mean age 48.8 ± 9.2 years, mean body mass index (BMI) 45.03 ± 4.82 kg/m²
- Participants
- 18 patients
- Exposure
- High vs low insulin resistance before and 6 months after SG
- High-IR (Hi-IR)n = 9
- Low-IR (Lo-IR)n = 9reference
- Outcome
- GM composition, incretin responses and metabolic outcomes after SG
- Follow-up
- 6 months post-surgery
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Mean % total weight loss
26.5 ± 6%
Observational data: associations, not effects.
Original publication
Insulin resistance modulates gut microbiota and incretin response remodeling after bariatric surgery in severe obesity. Int J Obes (Lond). Published 10 January 2026. doi:10.
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