Exercise reprograms the gut microbiota to enhance metabolic outcomes after bariatric surgery: a translational, cross-species study
Authors' conclusion
These findings suggest that exercise following bariatric surgery is associated with distinct gut microbial configurations and metabolic improvements, and that exercise-conditioned microbiota may contribute to aspects of host metabolic regulation after surgery.
Study context
- Population
- Women undergoing RYGB; Fecal microbiota transplantation (FMT) into high-fat diet-fed female mice32 randomized
- Participants
- 16 / 16 / 16
- Comparison
- RYGB plus 6-month exercise training vs RYGB alone
- RYGB + ETn = 16
- RYGBn = 16reference
- LEANn = 16
Methodological detailstranslational, cross-species
- Translational
- Cross-species
Primary result
As reported in the abstract
9 months post-surgery
- Comparable improvements in body composition and inflammation in both surgical groups
- Greater improvements in HDL, TG, fasting glucose and fasting insulin with RYGB + ET
- Exercise associated with increased gut microbiota α-diversity and shifts in composition, incl. enrichment of genera linked to short-chain fatty acid (SCFA) metabolism
Further findings
FMT into 36 high-fat diet-fed female mice (rRYGB, rRYGB+ET, rLEAN) · donor microbiota at POST9
- rRYGB+ET vs rRYGB: similar inflammatory status and glucose tolerance
- rRYGB+ET vs rRYGB: lower fasting insulin and HOMA-IR, partial preservation of intestinal morphology
Original publication
Exercise reprograms the gut microbiota to enhance metabolic outcomes after bariatric surgery: a translational, cross-species study. Int J Obes (Lond). Published 4 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →