Systematic comparison of triglyceride-glucose (TYG)-index with other mortality predictive models in obese patients with different mortality rates
Authors' conclusion
In obesity, TyG-based indices are associated with long-term mortality risk but add limited prognostic value beyond age and multimorbidity burden. These markers may be considered complementary tools for metabolic characterization rather than primary instruments for mortality risk stratification. This study reinforces the concept that various mortality indexes are as valid as, or even more predictive than, TYG index.
Study context
- Population
- Adults with obesity in two independent cohorts with different mortality ratestwo cohorts
- Participants
- 1,359 vs 854
- Comparison
- TyG index vs TyG-BMI, blood glucose, age, Charlson Index, metabolic syndrome, glucose tolerance and DM as mortality predictors
- General obesityn = 1,359
- Bariatric surgeryn = 854
- Outcome
- All-cause mortality prediction (Cox models with Harrell's C index; ROC analysis)
- Follow-up
- Approaching 14 years
Methodological detailstwo independent cohorts, long-term follow-up approaching 14 years
- Two independent cohorts
- Long-term follow-up approaching 14 years
Performance
As reported in the abstract
All-cause mortality prediction
General obesity
11.5
%
Bariatric surgery
5.5%
- The various indexes significantly predicted mortality in Cox models
- p always < 0.001
- Harrell's C index correlated with ROC AUC of each index
- P < 0.001
Original publication
Systematic comparison of triglyceride-glucose (TYG)-index with other mortality predictive models in obese patients with different mortality rates. Cardiovasc Diabetol. Published 3 June 2026. doi:10.
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