Fecal microbiota transplantation in obesity metabolism: A meta analysis and systematic review
Authors' conclusion
FMT is more advantageous for obese patients with elevated blood pressure, disordered glucose and insulin metabolism, and elevated blood lipids. The study of metabolic factors in obese patients will be our starting point in the future.
Study context
- Population
- Obese/metabolic syndrome patients
- Participants
- 334 patients10 studies
- Comparison
- Fecal microbiota transplantation (FMT) from lean donors vs placebo
- Outcome
- Clinically significant parameters of obesity and metabolic syndrome (change before vs after treatment)
Pooled result
As reported in the abstract
- FMT significantly and negatively associated with most indices of abdominal adiposity incl. caloric intake, fasting glucose, HOMA-IR, systolic and diastolic BP, total cholesterol, HDL, LDL, TG and CRP
- Obesity parameters incl. fasting glucose and acetic acid increased following FMT
Original publication
Fecal microbiota transplantation in obesity metabolism: A meta analysis and systematic review. Diabetes Res Clin Pract. Published 24 June 2023. doi:10.
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