Diabetic Status, Advanced Age, and Hispanic Ethnicity Predict Poorer Weight Loss in Patients With Obesity Receiving Semaglutide
Authors' conclusion
This study suggested weight loss with weekly semaglutide was influenced by specific factors, including diabetes status, older age, and Hispanic ethnicity in our real-world clinic, although further research is needed to define prognosticators of weight loss across populations.
Study context
- Population
- Patients with BMI >25 kg/m² taking weekly semaglutide for at least 12 months, gastroenterology-based multidisciplinary obesity clinic, New York Cityof 294 prescribed
- Participants
- 163 patients
- Exposure
- Predictors of weight loss on weekly semaglutide
- Outcome
- %TWL on weekly injectable semaglutide
- Follow-up
- 12 months
Methodological detailsreal-world, single-centre
- Real-world
- Single-centre
Main finding
As reported in the abstract
Weight loss
- Mean weight loss
- 8.1 ± 18.5 kg
- Mean %TWL
- 8.1% ± 8.3%
- Hispanic ethnicity associated with reduced weight loss (univariable), 95% CI
- −6.82 to −0.55; P = .02
- History of T2D associated with reduced weight loss (univariable), 95% CI
- 0.74-5.76; P = .01
- Age >60 years associated with reduced weight loss (univariable), 95% CI
- −14.76 to −2.41; P = .007
- GI side effects not associated with weight loss outcomes, 95% CI
- 1.86-3.36; P = .57
- Provider visit number not associated with weight loss outcomes, 95% CI
- 0.15-0.28; P = .56
Observational data: associations, not effects.
Secondary outcomes
Failure to achieve 5% TWL: Hispanic ethnicity
- Hispanic ethnicity, OR
- 0.32 (95% CI 0.14-0.74)
- Multivariable regression
Original publication
Diabetic Status, Advanced Age, and Hispanic Ethnicity Predict Poorer Weight Loss in Patients With Obesity Receiving Semaglutide. Endocr Pract. Published 4 June 2026. doi:10.
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