Intravenous Oxytocin Has no Effect on Ad Libitum Food Intake or Postprandial Plasma Glucose Concentrations in Individuals With Obesity: A Randomised, Placebo‐Controlled, Double‐Blind, Crossover Study
Authors' conclusion
In individuals with obesity, 4.5-hour intravenous infusion of oxytocin causing supraphysiological plasma concentrations of ~400 pg/mL has no effect on ad libitum food intake, appetite sensations, plasma glucose levels, circulating concentrations of glucose and appetite-regulating hormones, or gastric emptying.
Study context
- Population
- Overnight fasted individuals with obesity; median age 41.5 years, BMI 36.2 kg/m², 12 womencompleted crossover
- Participants
- 24 participants
- Comparison
- IV oxytocin infusion vs placebo
- Primary endpoint
- Ad libitum food intake (ad libitum meal test)
- Follow-up
- After four hours
Methodological detailscrossover, double-blind, placebo-controlled
- Crossover
- Double-blind
- Placebo-controlled
Primary result
As reported in the abstract
Ad libitum food intake
Further findings
Appetite sensations, glucose, appetite-regulating hormones and gastric emptying (paracetamol)
- Oxytocin vs placebo did not affect appetite sensations nor circulating glucose, insulin, C-peptide, glucagon, GLP-1, GIP, cholecystokinin, or paracetamol
Original publication
Intravenous Oxytocin Has no Effect on Ad Libitum Food Intake or Postprandial Plasma Glucose Concentrations in Individuals With Obesity: A Randomised, Placebo‐Controlled, Double‐Blind, Crossover Study. Diabetes Obes Metab. Published 10 March 2026. doi:10.
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