Obesity

Tripeptide gut hormone infusion does not alter food preferences or sweet taste function in volunteers with obesity and prediabetes/diabetes but promotes restraint eating: A secondary analysis of a randomized single‐blind placebo‐controlled study

Diabetes Obes MetabPublished Secondary analysis of a randomised controlled trial

Authors' conclusion

The elevation in plasma GOP concentrations after RYGB is unlikely to mediate changes in food preferences and sweet taste function after surgery but may promote restraint eating.

Study context

Population
Subjects with obesity and prediabetes/diabetes
Participants
24 subjects
Comparison
Subcutaneous GLP-1, oxyntomodulin (OXM) and PYY infusion vs 0.9% saline for 4 weeks
Methodological detailssingle-blind, placebo-controlled, matched RYGB cohort for comparison
  • Single-blind
  • Placebo-controlled
  • Matched RYGB cohort for comparison

Primary result

As reported in the abstract

Food preferences, sweet taste function and eating behaviour · 4 weeks

Mean daily energy intake reduced with GOP

27%

Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.

Original publication

Tripeptide gut hormone infusion does not alter food preferences or sweet taste function in volunteers with obesity and prediabetes/diabetes but promotes restraint eating: A secondary analysis of a randomized single‐blind placebo‐controlled study. Diabetes Obes Metab. Published 13 March 2023. doi:10.1111/dom.15028

Composed by AI from the published abstract and checked against it. How Briefs are made →

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