The postprandial secretion of peptide YY1‐36 and 3‐36 in obesity is differentially increased after gastric bypass versus sleeve gastrectomy
Authors' conclusion
There appears to be no difference in PYY secretion between nonobese and obese volunteers at baseline. At 1 year after surgery, RYGB, but not SG, is associated with increased postprandial secretion of PYY1-36 and PYY3-36 , which may account for long-term differences in efficacy and adverse effects between the two types of surgery.
Study context
- Population
- Participants with obesity undergoing RYGB or sleeve gastrectomy (SG) at the Imperial Weight Centre, and healthy nonobese volunteers; standardized mixed meal test (MMT) before and 1 year after surgery
- Participants
- 24 / 6 / 10
- Exposure
- RYGB vs SG
- RYGBn = 24
- SGn = 6reference
- Healthy nonobese volunteersn = 10
- Outcome
- Fasting and postprandial PYY1-36 and PYY3-36 concentrations (LC-MS/MS assay)
- Follow-up
- 1 year after surgery
Main finding
As reported in the abstract
Postprandial PYY1-36 and PYY3-36 secretion · 1 year
- Postprandial secretion of both PYY1-36 and PYY3-36 amplified after RYGB, but not SG; response significantly higher in RYGB vs SG
- RYGB vs SG: response significantly higher with RYGB
Observational data: associations, not effects.
Further findings
Presurgery fasting and postprandial PYY1-36 and PYY3-36
- Levels low with minimal MMT responses; did not differ from healthy nonobese volunteers
Original publication
The postprandial secretion of peptide YY1‐36 and 3‐36 in obesity is differentially increased after gastric bypass versus sleeve gastrectomy. Clin Endocrinol (Oxf). Published 28 November 2022. doi:10.
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