Effect of Semaglutide on Dumping Syndrome and Post-Bariatric Hypoglycemia After Roux-en-Y Gastric Bypass: A Single-Center Retrospective Study
Authors' conclusion
Semaglutide was associated with fewer clinically significant hypoglycemic events, improved dumping symptoms, and better CGM metrics over 12 months. Variable response and worsening hypoglycemia in a minority support individualized titration and close monitoring.
Study context
- Population
- Adults at least 12 months post-RYGB with refractory post-bariatric hypoglycemia (PBH)/dumping syndrome, with Whipple-triad-compatible postprandial symptoms with ambulatory and/or mixed-meal tolerance test support, completing 12 months of semaglutide (0.25–2.4 mg/week); 83.0% female, 42.7 ± 7.1 years oldadults completing 12 months of semaglutide
- Participants
- 100 adults
- Outcome
- Monthly clinically significant hypoglycemic events: Level 3 events requiring assistance and/or verified symptomatic Level 2 events (<54 mg/dL)
- Follow-up
- 12 months
Main finding
As reported in the abstract
- Clinically significant hypoglycemic events, baseline
- 4.90 ± 2.12
- Clinically significant hypoglycemic events at 12 months
- 3.26 ± 2.68/month
- Change from baseline
- p < 0.0001
Observational data: associations, not effects.
Further findings
Response categories
- Complete resolution
- 15%
- ≥50% reduction without resolution
- 26%
- Suboptimal response
- 47%
- Worsening hypoglycemia
- 12%
Sigstad scores
- Sigstad score, before
- 12.68 ± 2.63
- Sigstad score, after
- 9.13 ± 3.82
- Change
- P < 0.0001
CGM Time Below Range <54 mg/dL
- Before
- 5.06%
- After
- 2.58%
- Change
- P < 0.0001
CGM Time In Range
- Before
- 61.2%
- After
- 76.2%
- Change
- P < 0.0001
Follow-up
- Follow-up averaged
- 14.9 ± 1.8 months
- Years post-RYGB
- 2.8 ± 1.4 years
Safety
- Nausea (most common)
- 24.0%
- No serious adverse events occurred
Original publication
Effect of Semaglutide on Dumping Syndrome and Post-Bariatric Hypoglycemia After Roux-en-Y Gastric Bypass: A Single-Center Retrospective Study. Endocr Pract. Published 9 November 2026. doi:10.
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