Relationship Between Symptom Perception and Postprandial Glycemic Profiles in Patients With Postbariatric Hypoglycemia After Roux-en-Y Gastric Bypass Surgery
Authors' conclusion
The relationship between symptom perception and PBH is complex, challenging clinical judgement and decision-making in this population.
Study context
- Population
- Patients with post-bariatric surgery hypoglycemia (PBH) after RYGB; age 50.1 [41.6–60.6] years, 86.7% female, BMI 26.5 [23.5–31.2] kg/m² (median [IQR])
- Participants
- 30 patients
- Outcome
- Relationship between self-reported symptoms and postprandial sensor glucose profiles
- Follow-up
- 50 days
Methodological detailsblinded CGM (Dexcom G6), 50-day symptom recording
- Blinded CGM (Dexcom G6)
- 50-day symptom recording
Main finding
As reported in the abstract
Distribution of reported symptoms (775 symptoms in 5,851 postprandial periods)
Symptoms in postprandial periods without hypoglycemia, median (IQR)
30.6 (0.0-59.9)%
Symptoms in preceding dynamic phase of postprandial periods with hypoglycemia
16.7 (0.0-30.1)%
Symptoms in hypoglycemic phase of postprandial periods with hypoglycemia
45.0 (13.7-84.7)%
Observational data: associations, not effects.
Further findings
Symptoms in hypoglycemic phase, by symptom type
%
- Autonomic
- 53.6 (23.8-100.0)
- Neuroglycopenic
- 30.0 (5.6-80.0)
- Gastrointestinal
- 10.4 (0.0-50.0)
Glucose dynamics, nadir glucose and symptom perception
- Both faster glucose dynamics and lower nadir sensor glucose levels were related with symptom perception
Original publication
Relationship Between Symptom Perception and Postprandial Glycemic Profiles in Patients With Postbariatric Hypoglycemia After Roux-en-Y Gastric Bypass Surgery. Diabetes Care. Published 27 July 2023. doi:10.
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